Immunization withLeishmaniaVaccine-Alum-BCG and Montanide ISA 720 Adjuvants Induces Low-Grade Type 2 Cytokines and High Levels of IgG2 Subclass Antibodies in the Vervet Monkey (Chlorocebus aethiops) Model
نویسندگان
چکیده
منابع مشابه
Safety data of Montanide ISA 51 VG and Montanide ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
Introduction Montanide ISA 51 VG and Montanide ISA 720 VG are two novel adjuvants dedicated to human therapeutic vaccines. They have been used in more than 200 clinical trials involving cancer, AIDS, malaria or autoimmune disease vaccines and involving an accrual of more than 20000 patients. The adjuvants are rendering stable water-in-oil emulsions when mixed with water based antigenic media. M...
متن کاملThe genome of the vervet (Chlorocebus aethiops sabaeus).
We describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (SIV), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numb...
متن کاملSustained release of actives with Montanide™ ISA 51 VG and Montanide™ ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
Introduction MontanideTM ISA 51 VG and MontanideTM ISA 720 VG are adjuvants dedicated to human therapeutic vaccines. The adjuvants are rendering stable water-in-oil (W/O) emulsions when mixed with water phase. In these formulations the active ingredients are entrapped in droplets of water surrounded by continuous oil phase. It allows a protection against degradation and slow release of the acti...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Montanide ISA 720 is more effective than BCG as an adjuvant for Leishmania killed vaccine in BALB/c mice
The aim of this study was to evaluate the immunogenicity and efficacy of Montanide ISA 720 against BCG and alum as an adjuvant for Leishmania killed vaccine in BALB/c mice. Groups of mice were immunized with either, Baccile Calmette Guerin (BCG), aluminium hydroxide (alum) or Montanide ISA 720 (MISA) with killed Leishmania major (KLM) promastigotes antigen and later, sacrificed or challenged wi...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2012
ISSN: 0300-9475
DOI: 10.1111/j.1365-3083.2012.02764.x